Peptide-functionalized nanoparticles

Precision Delivery, Tailored Solutions: Peptide-Functionalized Nanoparticles for Next-Generation Therapies.

Industrial gap covered

One of the greatest challenges in nanomedicine is the delivery of therapeutically relevant amounts of drugs to specific body tissues or organs, hampering the development of new therapies. To favor the delivery to specific targets, the nanocarrier surface can be functionalized with moieties that specifically recognize targets that are predominantly present at the site of delivery. Peptides are one of the major classes of targeting molecules that are being investigated, and have gained increasing attention due to lower production costs compared to antibodies and easier processes to obtain functional chemical modifications. By now, many peptide sequences have been identified for different targets, and several modifications and chemical approaches can be applied to improve their selection, binding affinity, stability, and specificity.

Description

In this cutting-edge, we offer the preparation of tailored (lipid) nanoparticles functionalized with specific targeting peptides. The peptides are synthesized and characterized by HPLC-MS and HPLC and then are adequately modified to be conjugated on specific moieties/components (ie: lipids) that facilitate their integration into lipid nanoparticles and accessibility for binding, etc. The functionalized nanoparticles can be prepared using our scalable DELOS-SUSP method or microfluidics using the components that contain the targeting peptide, and purified using tangential flow filtration. A posterior physicochemical characterization can be done using different techniques such as DLS, ELS, MADLS, NTA, ITC, etc.

The final cost of this service may vary. More information can be found in our webpage (<a href="https://www.nanbiosis.es/preparation-of-peptide-functionalized-nanoparticles/">click here</a>).